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  • Title: Disintegrating force as a new formulation parameter.
    Author: Colombo P, Conte U, Caramella C, Geddo M, La Manna A.
    Journal: J Pharm Sci; 1984 May; 73(5):701-5. PubMed ID: 6737250.
    Abstract:
    Some coated aspirin tablet formulations were evaluated by relating their properties to disintegrating force development patterns. The treatment of disintegrating force-time curves was effected using the Weibull distribution as proposed for dissolution. Such parameters as the maximum disintegrating force developed, the time needed to reach 63.2% maximum disintegrating force (tau d) the shape parameter, the lag time, and the input value were used for evaluating the formulas examined. It was concluded that the input values, the integrating force development rate at tau d, can be employed as a new formulation parameter since, when correlated with the crushing strength, it allows an overall evaluation of the formula examined.
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