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  • Title: Synthesis of potential antifilarial agents. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl- and -arylureas.
    Author: Ram S, Skinner M, Kalvin D, Wise DS, Townsend LB, McCall JW, Worth D, Ortwine D, Werbel LM.
    Journal: J Med Chem; 1984 Jul; 27(7):914-7. PubMed ID: 6737434.
    Abstract:
    A series of 1-(5-benzoylbenzimidazol-2-yl)-3-substituted ureas have been synthesized by reacting an appropriate isocyanate with 2-amino-5-benzoylbenzimidazole or by reacting methyl (5-benzoylbenzimidazol-2-yl)carbamate with various amines. Several of the compounds have demonstrated antifilarial activity against Brugia pahangi and Litomosoides carinii.
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