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  • Title: Comparison of estrogen-induced hyperplasia to endometrial carcinoma.
    Author: Bhagavan BS, Parmley TH, Rosenshein NB, Jefferys JL, Grisso JA, Stolley PD.
    Journal: Obstet Gynecol; 1984 Jul; 64(1):12-5. PubMed ID: 6738936.
    Abstract:
    Use of exogenous estrogens has been associated with endometrial cancer in a number of case-control studies. This observed association could be biased as a result of frequent misclassification of estrogen-induced hyperplasia as endometrial cancer. To evaluate this possibility, pathology slides from 233 patients with a hospital diagnosis of endometrial cancer were reviewed independently by two pathologists. The hospital diagnosis was confirmed by both pathologists in 86% of the cases, indicating that the misclassification of hyperplasia as carcinoma is uncommon.
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