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  • Title: Successful results of a program combining live and inactivated poliovirus vaccines to control poliomyelitis in Gaza.
    Author: Lasch EE, Abed Y, Abdulla K, El Tibbi AG, Marcus O, El Massri M, Handscher R, Gerichter CB, Melnick JL.
    Journal: Rev Infect Dis; 1984; 6 Suppl 2():S467-70. PubMed ID: 6740094.
    Abstract:
    Trivalent oral poliovirus vaccine ( TOPV ) has been used in Gaza since 1967. After an initial decrease of 33% in the incidence of the paralytic disease, no further decrease could be noted. The mean annual incidence until 1977 was 10 per 100,000 inhabitants. Two outbreaks caused by poliovirus type 1 were registered in 1974 and 1976 with an incidence of 18 per 100,000 inhabitants. In these outbreaks, 34% and 50% of the affected children, respectively, had received three to four doses of TOPV . A new vaccination schedule was introduced in 1978, combining live and inactivated poliovirus vaccines. In the years 1978-1980, the incidence decreased to 2.6 per 100,000 inhabitants; and during 1981-1982, only three cases were recorded. These results indicate that a schedule like the one used in Gaza could serve as a model to control poliomyelitis in developing countries where TOPV alone is not successful.
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