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  • Title: [Effect of diets containing plant protein on liver mono-oxygenase activity in rats].
    Author: Zaboikina TN, Gapparov MM.
    Journal: Vopr Pitan; 1984; (2):41-2. PubMed ID: 6741019.
    Abstract:
    Male Wistar rats kept for 30 days on the diet containing vegetative (wheat) protein demonstrate an increase in cytochrome P-450 concentration in liver microsomes and an increase in the rate of amidopyrine N-demethylation and aniline p-hydroxylation. Administration of phenobarbital leads to cytochrome P-450 induction and activation of monooxygenase of rat liver microsomes, the quality of food protein not affecting cytochrome induction. It is assumed that high content of cytochrome P-450 is linked with prolongation of the time of cytochrome P-450 renewal at the expense of the decreased constant of its protein part degradation or with activation of cytochrome synthesis de novo (based on the preliminary data).
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