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  • Title: [Penetration of ampicillin and oxacillin into the tissues of rats with aseptic inflammation].
    Author: Agapitova IV, Bobrov VI, Trubnikov VI, Iakovlev VP.
    Journal: Antibiotiki; 1984 May; 29(5):370-3. PubMed ID: 6742809.
    Abstract:
    Penetration of 2 penicillins with different indices of serum protein binding in the tissues of rats with aseptic inflammation was studied. The pharmacokinetics of both penicillins in the blood serum (total preparation) did not differ. However, the level of the ampicillin free fraction was much higher than that of oxacillin. In the inflammation exudate and inflamed tissues, the maximum concentrations of free ampicillin and the area below its pharmacokinetic curve were also higher than those of oxacillin. The rate of elimination of both antibiotics from the exudate was the same. The period of half elimination of the drugs from the exudate and inflamed tissue was significantly higher than the period of their half elimination from the blood serum. High positive correlation between the ampicillin levels in the blood serum and inflamed and intact tissues was shown. As for oxacillin, positive correlation between its levels in the blood serum and inflamed tissue was observed.
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