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  • Title: The inhibition of both initiation and elongation of adenovirus DNA replication by actinomycin D.
    Author: Pincus S, Rekosh D.
    Journal: Biochem Biophys Res Commun; 1984 Jun 29; 121(3):1033-41. PubMed ID: 6743315.
    Abstract:
    The effect of actinomycin D on adenovirus DNA replication has been examined both in vivo and in a cell-free extract capable of replication on exogenously added template. In both cases we show that 5 micrograms/ml of drug cause an inhibition of DNA synthesis of at least 80%. The in vitro results further demonstrate that both DNA chain growth (elongation) and initiation - the addition of the first nucleotide of the DNA chain (dCMP) to the preterminal protein - are inhibited directly by the drug, by not by alpha-amanitin.
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