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  • Title: Effect of quinidine on the intestinal secretion of digoxin in guinea pigs.
    Author: Schäfer SG, Fichtl B, Doering W.
    Journal: Biopharm Drug Dispos; 1984; 5(2):163-8. PubMed ID: 6743783.
    Abstract:
    Following i.v. injection of digoxin (10 micrograms kg-1) the ratio between digoxin concentrations in the lumen of jejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearly with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In quinidine treated animals (100 mg kg-1 p.o., 2 h before experiment) both the L/P ratio (5.7; p less than 0.01) and the digoxin content of jejunal tissue (-32 per cent; p less than 0.01) were markedly reduced. It is suggested that quinidine reduces the extrarenal clearance of digoxin at least in part by inhibiting the intestinal secretion of this glycoside.
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