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  • Title: [Effect of 1-(chloromethyl)silatrane on biochemical indices in the tissue of experimental gastric ulcer].
    Author: Kuznetsov IG, Slutskiĭ LI, Suslova SK, Gol'dberg OA, Voronkov MG.
    Journal: Biull Eksp Biol Med; 1984 Jun; 97(6):658-60. PubMed ID: 6743799.
    Abstract:
    It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.
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