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  • Title: [Relation of proliferating to nonproliferating spleen cell populations during the development of Rauscher leukemia and after loading the mononuclear phagocyte system with colloidal gold].
    Author: Alekhina RP, Bukhman VM, Likhtenshteĭn AV, Shapot VS.
    Journal: Biull Eksp Biol Med; 1984 Jun; 97(6):713-5. PubMed ID: 6743812.
    Abstract:
    Undulatory changes in the ratio of proliferating to quiescent spleen cells of (C57BL/6j X DBA/2)F1 male mice were revealed in the course of Rauscher's leukemia development by means of nucleoprotein-celite chromatography. Administration of colloidal gold particles for the purpose of the functional loading of the mononuclear phagocyte system (MPS) induced a temporary diminution (for several hours) of the proliferating cell percentage and the DNA synthesis rate. Then the number of proliferating cells returned to normal (by 24 hours), with the DNA synthesis rate exceeding the basic level. The data obtained point to the dependence of tumor cell proliferation on the MPS in Rauscher's leukemia.
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