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  • Title: Inhibition by N-(phosphonacetyl)-L-aspartate of Ehrlich ascites tumour growth and glucose transport.
    Author: Leung SW, Fung KP, Choy YM, Lee CY.
    Journal: Cancer Lett; 1984 Jun; 23(2):183-8. PubMed ID: 6744243.
    Abstract:
    N-(Phosphonacetyl)-L-aspartate (PALA) suppressed the growth of Ehrlich ascites tumour cells in vivo in a dose-dependent manner. Simultaneously as the growth rate decreased, the cellular uptake of glucose and the density of a class of glucose-reversible binding sites for cytochalasin B on the cell surface were also found to be reduced. There is a highly significant correlation between the magnitude of changes in the number of cytochalasin B binding sites and the magnitude of changes in glucose uptake. The physiological significance of these observations are discussed.
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