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  • Title: Beta-tricalcium phosphate delivery system for bone morphogenetic protein.
    Author: Urist MR, Lietze A, Dawson E.
    Journal: Clin Orthop Relat Res; 1984; (187):277-80. PubMed ID: 6744730.
    Abstract:
    An aggregate of biodegradable beta-tricalcium phosphate and bone morphogenetic protein (BMP/TCP) induces the differentiation of cartilage within eight days, cartilage and woven bone within 12 days, and lamellar bone, including bone marrow, within 21 days. The yield of new bone from a 1-mg dose was more than 12 times greater from the TCP/BMP than from the BMP alone. Whether TCP acts as a slow-release delivery system, potentiates the activity of BMP, or serves to distribute BMP in a favorable three-dimensional pattern requires further investigation.
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