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  • Title: [Characterization of slow reacting substance of anaphylaxis in asthmatic sputum].
    Author: Wang SR, Yang CM, Wang SM.
    Journal: Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi; 1984 Feb; 17(1):48-54. PubMed ID: 6744994.
    Abstract:
    Sputum from asthmatics contained a mediator similar to slow reacting substance of anaphylaxis (SRS-A), capable of inducing contraction of guinea pig ileum. This mediator possessed the major characteristics of SRS-A, including stability in both neutral and alkaline solutions, lability in boiling acidic solution, destruction by arylsulfatase, inhibition by FPL 55712 and resistance to diphenhy dramine . Thus, we proved that the "SRS-A like" mediator was in fact SRS-A. The activity of histamine in these patients' sputa could be inhibited only by diphenhydramine, but could not be altered by any of the other treatments noted above.
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