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  • Title: Isolation and chemical conversion of two novel prostaglandin endoperoxides: 5(6)-epoxy-PGG1 and 5(6)-epoxy-PGH1.
    Author: Oliw EH.
    Journal: FEBS Lett; 1984 Jul 09; 172(2):279-83. PubMed ID: 6745418.
    Abstract:
    5(6)-Epoxy-PGG1 and 5(6)-epoxy-PGH1 were isolated after incubation of microsomes of RSV with 3H-labelled 5(6)-epoxy-C20:3 for 45 s at 37 degrees C. The endoperoxides were methylated and characterized by conversion to prostaglandins. In buffer, the endoperoxides were converted to methyl-5(6)-epoxy-PGE1 and methyl-5(6)-epoxy-15-hydroperoxy-PGE1, while treatment with SnCl2 reduced the endoperoxides to methyl-5-hydroxy-PGI1 alpha and methyl-5-hydroxy-PGI1 beta. Significant amounts of methyl-5(6)-epoxy-HHD were also formed. The endoperoxides could be separated by silicic acid chromatography and when 1 mM phenol was present in the incubation, 5(6)-epoxy-PGH1 was obtained as the main product.
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