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  • Title: Adrenal adenoma with 18-hydroxycorticosterone excess and hypertension: a variant of aldosteronomas.
    Author: Kigoshi T, Imaizumi N, Azukizawa S, Yamamoto I, Hosojima H, Uchida K, Morimoto S.
    Journal: Horm Res; 1984; 19(4):224-31. PubMed ID: 6745843.
    Abstract:
    A 46-year-old woman with hypertension, normokalemia, suppressed renin, normal catecholamines, and a left adrenal mass on the CT scan was found to have excessive 18-hydroxycorticosterone (18-OHB) and normal aldosterone levels in plasma, both of which responded poorly to sodium restriction and angiotension II, and supranormally to ACTH. Plasma 18-hydroxydeoxycorticosterone (18-OHDOC) was normal. After adrenalectomy, amelioration from hypertension occurred with a reduction in plasma 18-OHB and aldosterone. The plasma 18-OHDOC remained normal. The adrenal tumor was histologically an adenoma, containing a large amount of 18-OHB and a small amount of aldosterone. Thus, the present adenoma seems to be a variant of aldosteronomas.
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