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  • Title: Spectrophotometric determination of bromhexine hydrochloride in pharmaceutical preparations.
    Author: Santoro MI, dos Santos MM, Magalhães JF.
    Journal: J Assoc Off Anal Chem; 1984; 67(3):532-4. PubMed ID: 6746476.
    Abstract:
    The presence of an aromatic primary amino group in bromhexine HCl enables the use of diazotization-coupling, according to the classic Bratton-Marshall method, for its analysis in pharmaceutical preparations. Spectrophotometric parameters were established for standardization of the method, including statistical analysis of data. Substances such as potassium guaiacolsulfonate, ampicillin, cephalexin, oxytetracycline HCl, amoxycillin, and erythromycin ethylsuccinate do not interfere with the determination. The precision of the method is about 2.0%.
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