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Title: Sensitive gas-liquid chromatographic-electron-capture detection method for determination of sobrerol in biological fluids. Author: Shukla UA, Stetson PL, Wagner JG. Journal: J Chromatogr; 1984 Jun 08; 308():189-97. PubMed ID: 6746813. Abstract: A sensitive gas-liquid chromatographic assay for sobrerol in biological fluids has been developed. The assay procedure involves esterification of both hydroxyl groups of sobrerol with pentafluoropropionic anhydride to form the diester which can be quantitated using gas-liquid chromatography-electron-capture detection. The detection limit of plasma sobrerol under the conditions described is 5 ng/ml. The assay procedure permits the measurement of unchanged drug in plasma, whole blood or urine in the presence of its metabolites.[Abstract] [Full Text] [Related] [New Search]