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  • Title: [Peripheral circulatory effects of sodium nitroprussate. Evaluation by plethysmography and capillaroscopy].
    Author: Schmidt C, Chevreaud C, Borgo J, Miahle C, Gavoille R.
    Journal: J Mal Vasc; 1984; 9(2):101-6. PubMed ID: 6747470.
    Abstract:
    Circulatory effects of intravenous injection of sodium nitroprusside are appreciated in 6 patients by monitoring systemic pressure, heart rate, digital systolic pressure, pulse plethysmography and nail-fold capillaroscopy. Low doses of nitroprusside (1.5 microg./kg/mn) enhance digital blood flow (+ 78.9%) and maximum height of the plethysmographic curve (+ 71.6%), without any significant modification of the systemic blood pressure (- 0.6%), heart rate (+ 6.3%) and digital pressure (- 1.15%). The peripheral resistances are strongly reduced. Nail fold capillaroscopy is unchanged. Higher doses, even with an adequate vascular filling, are potentially harmful for microcirculation.
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