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  • Title: Studies on neurotransmitter receptor systems in neocortex and hippocampus in senile dementia of the Alzheimer-type.
    Author: Cross AJ, Crow TJ, Johnson JA, Perry EK, Perry RH, Blessed G, Tomlinson BE.
    Journal: J Neurol Sci; 1984 May; 64(2):109-17. PubMed ID: 6747659.
    Abstract:
    Ligand binding to alpha 1-, alpha 2- and beta-adrenergic, serotonin, benzodiazepine and GABA receptors was studied in neocortex and hippocampus of controls and patients with senile dementia of the Alzheimer-type. A selective loss of serotonergic binding sites characterised as a loss of both S1 and S2 sites was observed. The reduction in serotonin receptors did not correlate with a clinical assessment of the degree of dementia, or with the extent of Alzheimer-type neuropathological change.
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