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  • Title: Clinical comparison of ibuprofen, fenoprofen calcium, naproxen and tolmetin sodium in rheumatoid arthritis.
    Author: Gall EP, Caperton EM, McComb JE, Messner R, Multz CV, O'Hanlan M, Willkens RF.
    Journal: J Rheumatol; 1982; 9(3):402-7. PubMed ID: 6750117.
    Abstract:
    After baseline aspirin therapy, 89 rheumatoid arthritis patients completed a double-blind, crossover trial comparing ibuprofen, fenoprofen, naproxen, and tolmetin. Initially, patients took the manufacturer's recommended starting dose; this could be increased by 50% within the first 2 weeks of therapy. Patients remained at the chosen dose for 4 weeks and then changed to the next drug. All 4 drugs were tolerated better than aspirin (p less than 0.001). There were no statistically significant differences among the 4 drugs for any efficacy measurements. However, patients' and physicians' rankings showed the same order of preferences: naproxen, ibuprofen, fenoprofen, tolmetin, and aspirin.
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