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  • Title: Hemodynamic effects of captopril in pulmonary hypertension of collagen vascular disease.
    Author: Niarchos AP, Whitman HH, Goldstein JE, Laragh JH.
    Journal: Am Heart J; 1982 Oct; 104(4 Pt 1):834-8. PubMed ID: 6751058.
    Abstract:
    Captopril 12.5 to 50 mg as a single dose was given to six patients with pulmonary hypertension secondary to collagen vascular disease. Total pulmonary resistance was decreased in four patients from 19% to 39%, but mean pulmonary artery pressure (63 +/- 15 mm Hg) was not decreased, probably because of the concurrent increase in cardiac output from 21% to 52% (2p less than 0.05). The systemic arterial pressure was slightly decreased due to the decrease in total systemic resistance. Control plasma renin activity ranged from 0.15 to 16 ng/ml/hr and was increased during captopril from 19% to 356%. These results, although preliminary, suggest that captopril may be beneficial in certain patients with pulmonary hypertension secondary to collagen vascular disease.
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