These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inhibition of renin by conformationally restricted analogues of angiotensinogen.
    Author: Nakaie CR, Oliveira MC, Juliano L, Paiva AC.
    Journal: Biochem J; 1982 Jul 01; 205(1):43-7. PubMed ID: 6751323.
    Abstract:
    [Cys(5),Cys(10)]Angiotensinogen-(5-14)-peptide analogues and homologues were synthesized, in which a disulphide bond between residues 5 and 10 stabilized a 9-->6 beta-turn proposed for the substrate. These compounds were competitive inhibitors of human and pig renins with K(i) values of the order of 10(-6)-10(-5)m, indicating that the conformation proposed for the substrate is important for the interaction with the enzyme.
    [Abstract] [Full Text] [Related] [New Search]