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  • Title: Comparative studies of atropine methonitrate and its combination with reproterol in chronic airway obstruction.
    Author: Macha HN, Aurich R.
    Journal: Arzneimittelforschung; 1982; 32(7):774-6. PubMed ID: 6751338.
    Abstract:
    The therapeutic value of 80 micrograms atropine methonitrate delivered per metered aerosol and its combination with 450 micrograms reproterol was investigated in a controlled double-blind cross-over trial in 17 patients with chronic bronchitis and airway obstruction. All patients were atropine responders. According to the parameters of FEV1 and SGaw atropine methonitrate induced a statistically definite and clinically relevant bronchodilation for more than 3 h compared with placebo. The combination of 80 micrograms atropine methonitrate and 450 micrograms reproterol, however, proved to be clearly superior compared with the mono-compound atropine methonitrate.
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