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  • Title: Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectomized animals.
    Author: Fernandez Pardal J, Gimeno MF, Gimeno AL.
    Journal: Prostaglandins Leukot Med; 1982 Sep; 9(3):341-8. PubMed ID: 6752960.
    Abstract:
    The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous outflow. PGE2 augmented 3H-normetanephrine whereas PGE1 reduced the 3H-3, 4-dihydroxyphenylglycol fraction. The 3H-noradrenaline fraction from the spontaneous outflow of tritium was enhanced by PGE2 and PGI2 (10 nM). On the other hand PGF2 alpha (10 nM-1 microM) did not change the metabolism of 3H-noradrenaline. The present findings suggest a possible modulation of noradrenaline metabolism by some PGs on the isolated rat uterus from ovariectomized rats.
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