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  • Title: Effect of pirenzepine on meal-stimulated acid secretion and gastrin release in normal man.
    Author: Mignon M, Vatier J, Bauer P, Bonfils S.
    Journal: Scand J Gastroenterol Suppl; 1982; 72():145-51. PubMed ID: 6753112.
    Abstract:
    The effect of increasing doses of pirenzepine, a tricyclic compound and new antiulcer drug, on meal-induced gastric acid secretion, gastrin release and gastric emptying of the liquid meal, was investigated in eight healthy volunteers. Gastric acid secretion was assessed using intragastric titration technique. Intra-muscularly administered doses of pirenzepine tested were 0 (placebo), 0.1, 0.25 and 0.5 mg.kg-1. With increasing doses of pirenzepine a dose-related reduction of meal-stimulated acid response was noticed amounting to 53% of control values with the highest dosage. The IC 50 value is close to 200 ng.ml-1. Initial but not total gastric emptying of the liquid protein-meal was slowed by 0.5 mg.kg-1 pirenzepine dose. Gastrin responses to the meal were reduced in a dose dependent manner although to a lesser degree.
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