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  • Title: [Postoperative radiotherapy of astrocytomas grade 3 and 4 with the radiosensitizer misonidazole. -End results of a multicentric controlled German study].
    Author: Sack H, Calcanis A, Godehardt E, Weidtman V, Zülch KJ, Ammon J, Bamberg M, Herbst M, Keim H, Kleibel F, Makoski HB, Potthoff PC, Schlegel G, Schnepper E.
    Journal: Strahlentherapie; 1982 Aug; 158(8):466-9. PubMed ID: 6753245.
    Abstract:
    102 patients entered a multicentric randomized study from May 1978 till December 1980. After an operative removal of a supratentorial astrocytoma grade 3 or 4 all patients were treated by radiotherapy of the whole brain with 40 Gy, and after a rest of 1 to 2 weeks with a boost dose of 20 Gy to the tumor region. By randomization the patients got misonidazole (400 mg/m2) to each of the 30 fractions or a placebo. The overall tolerance was good. A mild transient peripheral neuropathy was seen only in 2 patients. The median of survival time was not significantly different for both groups with 16 months (grade 3) and 10 months (grade 4). Thus a radiosensitizing effect of misonidazole was not proven.
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