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  • Title: A gonadotrophin-releasing hormone (GnRH) antagonist inhibits GnRH- but not LH-induced meiosis in follicle-enclosed rat oocytes in vitro.
    Author: Ekholm C, Hillensjö T, Le Maire WJ, Magnusson C, Sheela Rani CS.
    Journal: Acta Endocrinol (Copenh); 1982 Oct; 101(2):264-7. PubMed ID: 6753436.
    Abstract:
    Previous studies have shown that gonadotrophin-releasing hormone (GnRH) can induce resumption of meiosis in follicle-enclosed rat oocytes. In the present study a GnRH antagonistic analogue ([D-pGlul,D-Phe2,-D-Trp3,6]LRF) was found to effectively abolish the stimulatory effect of a GnRH agonist upon resumption of meiosis and lactate accumulation in isolated pre-ovulatory rat follicles but the have no effect on LH stimulation of these parameters. It is concluded that although LH and GnRH can evoke a similar response they act through separate receptor sites and that it is unlikely that GnRH mediates the effect of LH on meiosis or glycolysis.
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