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  • Title: Long-term captopril treatment in moderate to severe hypertension.
    Author: Santucci A, Aguglia F, De Mattia G, Ficara C, Balsano F.
    Journal: Br J Clin Pharmacol; 1982; 14 Suppl 2(Suppl 2):77S-79S. PubMed ID: 6753908.
    Abstract:
    1 The long-term effects of the oral angiotensin-converting enzyme inhibitor captopril with the addition of a diuretic (chlorthalidone) were examined in 16 patients with moderate or grave hypertension. Of these, 14 had essential hypertension and two renovascular hypertension. 2 Blood pressure fell sharply in all patients and this antihypertensive effect was maintained during 2, 4, 6, 12, and 24-month follow-up periods. The efficacy of treatment was not predicted by basal values of plasma renin activity. 3 Urinary excretion of sodium and potassium increased, but the increases were never such as to modify significantly sodium and potassium serum concentration. 4 The long-term treatment was generally well tolerated.
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