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  • Title: Metoprolol for hypertension. Open trial in general practice.
    Author: Fredman RM.
    Journal: Med J Aust; 1982 Oct 16; 2(8):378-80. PubMed ID: 6755204.
    Abstract:
    The results of an uncontrolled and open study of a once-a-day dosage of metoprolol (Betaloc) in the management of mild to moderate hypertension are described. The study was conducted by a group general practice. The trial was designed to test if metoprolol taken only once a day, could improve patient compliance. This would also result in less expense to the patient. Of the 161 patients who started the trial, 144 patients remained in it. Hypertension was fully controlled in 84 patients, but 33 failed to respond to metoprolol therapy. Because of side effects, 27 abandoned the trial. The remaining 17 patients withdrew from the drug trial for reasons unrelated to metoprolol. The efficacy of metoprolol was not influenced by a person's sex, but the number of side effects was significantly increased in older patients.
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