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  • Title: [Parathormone and vitamin d3-metabolites in healthy children and children with chronic renal failure before and after kidney transplantation].
    Author: Pistor K, Reinhardt D, Grosse-Hohmann E, Keck E.
    Journal: Monatsschr Kinderheilkd; 1982 Sep; 130(9):714-20. PubMed ID: 6755227.
    Abstract:
    Immunoreactive parathyroid hormone (iPTH), 25(OH)D3, 24,25(OH)2D3, 1.25(OH)2D3, creatinin, phosphate and calcium were determined in 33 children suffering from chronic renal failure as well as in 7 healthy children serving as a control group. In 9 children with preterminal renal insufficiency and in 13 children who had to undergo hemodialysis iPTH and creatinin were closely related. In the hemodialysed children's group serum phosphate was significantly elevated whereas calcium did not different from the control group. Treatment with vitamin D3 showed in those children undergoing hemodialysis increased 25(OH)D3 in normal 1.25(OH)2D3 plasma levels. Nevertheless, in the children with preterminal renal insufficiency as well as the children under hemodialysis iPTH was significantly increased. Thus, it is suggested that a negative feed back regulation controls the synthesis of 1.25(OH)2D3. After kidney transplantation the serum levels of iPTH, the vitamin D3 metabolites and creatinin became normal. There was no correlation between iPTH and 25(OH)D3 or 1.25(OH)2D3, but the correlation with creatinin (P less than 0.05, r = 0.7) before and after transplantation was statistically significant. Thus, the alterations in vitamin D metabolism and the hyperparathyroidism in chronic renal osteodystrophy appear to be largely independent of each other.
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