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  • Title: [Anticentromere antibodies. Diagnostic and prognostic value].
    Author: Meyer O, Haïm T.
    Journal: Nouv Presse Med; 1982 Oct 09; 11(39):2891-4. PubMed ID: 6755388.
    Abstract:
    The results of investigations for antinuclear antibodies in scleroderma and other connective diseases are reported. An indirect fluorescence method on Hep-2 cell smears was used. Antibodies directed against chromosomal centromeres were detected in 25 cases: 19 sera of patients with diffuse scleroderma, 2 cases of Raynaud's disease, 2 cases of rheumatoid arthritis and 1 case each of lupus and dermatomyositis. A significant correlation was found between the presence of anticentromere antibodies and benign forms of scleroderma, notably the CREST syndrome.
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