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  • Title: [Decreased tissue sensitivity to insulin in rats after hydrocortisone or indomethacin administration: the association with prostaglandin action].
    Author: Kosovskiĭ MI, Khusainova FA, Guliamov TD.
    Journal: Probl Endokrinol (Mosk); 1982; 28(5):57-60. PubMed ID: 6755442.
    Abstract:
    Hydrocortisone or indomethacin injection to rats induces insulin hyposensitivity determined by the glycemic curve after insulin injection and by the glycogen content in the diaphragm and gastrocnemius muscle following incubation of these tissues with glucose and insulin. It is suggested that the effect of the drugs is caused by their ability to inhibit the biosynthesis of prostaglandins, which enhance the rate of glucose transport to cells. To study this problem to diaphragmatic and uterine tissues of healthy rats were incubated with prostaglandins E2 or F2 alpha in the presence of insulin and glucose. An increase in the tissue glucose absorption from the medium was observed under prostaglandin action. Therefore, one of the reasons for a decrease of the tissue sensitivity to insulin may lie in the inhibited prostaglandin biosynthesis in the tissues.
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