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  • Title: Characterization of two insulin-binding components of rat-liver plasma membranes.
    Author: Baron MD, Sönksen PH.
    Journal: Biosci Rep; 1982 Oct; 2(10):785-93. PubMed ID: 6756497.
    Abstract:
    We have identified and isolated two forms of insulin receptor from rat-liver plasma membranes. The smaller (Mr = 90k) is a single polypeptide. The same polypeptide appears to be the insulin-binding site of the larger Mr = 280k). Only the larger, multisubunit, receptor shows high-affinity binding of insulin and negative cooperativity in its dissociation kinetics.
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