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  • Title: Early origins of definitive erythroid cells in the chick embryo.
    Author: Dardick I, Setterfield G.
    Journal: Tissue Cell; 1978; 10(2):355-64. PubMed ID: 675670.
    Abstract:
    The early maturation stages of definitive erythroid cells are observed in the embryonic circulation of the chick yolk sac at 4.5--5 days of incubation. Light and electron microscope observation of the mesoderm of the yold sac membrane indicate that individual presumptive precursors of the definitive-line are present as early as 2 days of incubation and give rise to sequestered populations of immature erythroblasts within sinusoids during the period of 2.5-6 days incubation. Such isolated populations of definitive-line erythroblasts eventually connect with the established capillary circulation of yolk sac membrane but a large proportion of the erythroblasts temporarily remain associated with the endothelium prior to free circulation.
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