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  • Title: Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells.
    Author: Kreisberg JI, Karnovsky MJ, Levine L.
    Journal: Kidney Int; 1982 Oct; 22(4):355-9. PubMed ID: 6757529.
    Abstract:
    Prostaglandin production was measured in homogeneous cultures that had been characterized as glomerular epithelial and mesangial cells. Glomerular epithelial cells produced ten times more cyclooxygenase products than mesangial cells; 88 to 95% of its products were prostacyclin. Mesangial cells produced predominantly prostaglandin E2 (57 to 66%); only 14 to 15% of the prostaglandins produced by mesangial cells was PGI2. Cultured glomerular epithelial and mesangial cells produced little prostaglandin D2, thromboxane, 12-L-hydroxyeicosatetraenoic acid, or 6-sulfido-peptide-containing leukotrienes.
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