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  • Title: The activity of 2-(2',4'-diaminophenoxy)ethanol in 3 genetic toxicity bioassays.
    Author: Brusick DJ, Jagannath DR, Matheson D.
    Journal: Mutat Res; 1982 Dec; 102(4):361-72. PubMed ID: 6757738.
    Abstract:
    2-(2',4'-Diaminophenoxy)-ethanol, a hair-dye ingredient was evaluated for genetic activity in vitro using urine collected from mice in an Ames test and in vivo using the mouse dominant-lethal assay and the mouse spot test for somatic mutation detection. All 3 studies were conducted using dermal application of the dye material to shaved skin. The applied dose levels ranged from 15 to 1500 mg/kg body weight. The results of these 3 studies were considered to be negative although urine analysis and spot-test data showed non-significant dose-related increases.
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