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  • Title: [Effect of prostacyclin on cerebral vasospasm--an experimental study].
    Author: Quintana L, Konda R, Ishibashi Y, Okada H, Suzuki J.
    Journal: No Shinkei Geka; 1982 Oct; 10(10):1049-52. PubMed ID: 6757779.
    Abstract:
    Prostacyclin(PGI2), a strong vasodilator of cerebral vessels and a potent inhibitor of platelet aggregation, was infused intravenously in 7 cats after induction of prolonged vasospasm by hourly application of oxyhemoglobin solution into the subarachnoid space around the basilar artery. PGI2, at a concentration of 50 ng/kg/min, was effective in releasing the vasospasm in the 7 cats. On the other hand, PGI2 did not produce significant hypotension. This report will discuss our results and the probable mechanism of action of PGI2 in cerebral vasospasm.
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