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  • Title: A controlled double-blind study of femoxetine and amitriptyline in patients with endogenous depression.
    Author: Reebye PN, Yiptong C, Samsoon J, Schulsinger F, Fabricius J.
    Journal: Pharmacopsychiatria; 1982 Sep; 15(5):164-9. PubMed ID: 6757983.
    Abstract:
    The new selective serotonin (5-HT)-uptake inhibitor femoxetine was compared with amitriptyline in a double-blind clinical trial comprising 77 depressed patients. The depressive symptoms were evaluated with the Hamilton rating scale, and a global clinical evaluation. Both drugs showed an antidepressive effect and no significant differences were found. Femoxetine induced a significantly lower frequency of dry mouth and blurred vision; this difference is presumably due to the weak anticholinergic effect of this substance. A small but significant weight loss was observed in the femoxetine group but not in the amitriptyline group.
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