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  • Title: Mutagenicity of 2,4-dinitrotoluene and its metabolites in Salmonella typhimurium.
    Author: Mori MA, Miyahara T, Taniguchi K, Hasegawa K, Kozuka H, Miyagoshi M, Nagayama T.
    Journal: Toxicol Lett; 1982 Sep; 13(1-2):1-5. PubMed ID: 6758203.
    Abstract:
    2,4-Dinitrotoluene (2,4-DNT) and its metabolites (2A4NT, 4A2NT, 2,4-DNB, 2A4NB, 4A2NB, 2,4-DAT, 2N4AAT, 2A4AAT, 2A4AABA and 2,4-DNBA), and 2,4-dinitrobenzaldehyde (2,4-DNA1), putative metabolite of 2,4-DNT, were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100. 2,4-DAT, 2N4AAT, 2A4AAT, 2A4AABA and 2,4-DNBA were inactive for strains TA98 and TA100. 2,4-DNT itself was only a weak mutagen. Two aminonitrotoluenes (2A4NT and 4A2NT), two aminonitrobenzyl alcohols (2A4NB and 4A2NB) and 2,4-dinitrobenzyl alcohol (2,4-DNB) were increasingly mutagenic in that order, in both strains, however, they were only weak or weak mutagens at mM concentrations. In contrast with these compounds, 2,4-DNA1 was mutagenic even at microM concentrations in both strains. These results suggest that a high mutagenicity of 2,4-DNA1 may be correlated to the carcinogenicity of 2,4-DNT.
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