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  • Title: Increased deposition of 111Indium labelled platelets in chronically rejected kidney transplants.
    Author: Leithner C, Sinzinger H, Schwarz M, Pohanka E, Syre G.
    Journal: Clin Nephrol; 1982 Dec; 18(6):311-3. PubMed ID: 6759003.
    Abstract:
    Increased deposition of 111In-oxine labelled autologous platelets in chronically rejected kidney transplants was demonstrated using a gamma-camera and by measurement of a platelet uptake index (PUI). In this group of patients the PUI correlated indirectly with the platelet half-life and was statistically different from the PUI found in stable transplant patients who acted as controls. It is therefore suggested that platelets may play a key role in chronic rejection by the release of a mitogenic factor which promotes the development of obliterative arterial lesions in the transplant.
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