These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Calcium intake regulates 1,25-dihydroxy-vitamin D formation in the diabetic rat.
    Author: Wilson HD, Horst RL, Schedl HP.
    Journal: Diabetes; 1982 May; 31(5 Pt 1):401-5. PubMed ID: 6759256.
    Abstract:
    Duodenal calcium absorption and serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations are decreased and body growth is arrested in the streptozotocin-diabetic rat taking commercial chow with high (1.2-2%) calcium content. Treatment with insulin restores 1,25-(OH)2D3, calcium absorption, and body growth to normal. We hypothesized that the depressed 1,25-(OH)2D3 in diabetics is due in part to the minimal requirement for vitamin-D-mediated intestinal calcium transport under conditions of arrested growth and high calcium intake. We tested this hypothesis by comparing the response of serum 1,25-(OH)2D3 concentration to low (0.02%) and normal (0.5%) calcium diets in control and streptozotocin-diabetic rats. To evaluate response to short-term insulin treatment, serum 1,25-(OH)2D3 was measured after 12 or 36 h of treatment. Serum 1,25-(OH)2D3 concentrations in the 0.5% calcium diet groups were 175, 25, and 120 pg/ml for control, diabetic, and insulin-treated 36-h groups, respectively. Low calcium diets increased concentration to 625, 100, and 370 pg/ml for controls, diabetics, and insulin-treated 36-h groups, respectively. In conclusion, the diabetic retains the ability to respond to calcium deficiency, even in the insulin-deficient state. Low calcium intake, in addition to enhancing 1,25-(OH)2D3 formation in diabetics, also modulates the response to insulin treatment. These studies demonstrate that the regulatory factor(s) suppressing serum, 1,25-(OH)2D3 in diabetes is not simply insulin deficiency per se. Implications of these findings for diabetes are discussed.
    [Abstract] [Full Text] [Related] [New Search]