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  • Title: Comparison of insulin receptor binding to monocytes and erythrocytes in newly diagnosed type II diabetes mellitus.
    Author: Prager R, Schernthaner G.
    Journal: Horm Metab Res; 1982 Nov; 14(11):561-3. PubMed ID: 6759349.
    Abstract:
    Insulin binding to circulating monocytes and erythrocytes was studied in 20 healthy volunteers and in 25 obese hyperinsulinemic newly diagnosed type-II diabetics. In type-II diabetics insulin binding to monocytes as well as to erythrocytes was significantly decreased in comparison with healthy individuals. The lowered insulin binding of the diabetics was mainly caused by a loss of receptor number. Individual analysis of the binding data, however, shows a marked discrepancy between receptor binding to circulating monocytes compared with erythrocytes. Since insulin binding to erythrocytes shows a great variation and seems to be influenced by other factors beside insulin concentrations it is suggested that insulin receptors on monocytes should be preferred for evaluation of peripheral insulin sensitivity.
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