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  • Title: Genotoxicity of flavoring agents.
    Author: Kasamaki A, Takahashi H, Tsumura N, Niwa J, Fujita T, Urasawa S.
    Journal: Mutat Res; 1982 Dec; 105(6):387-92. PubMed ID: 6759930.
    Abstract:
    The genotoxicity of 9 flavoring agents widely used in everyday foods was studied by a bacterial mutation test in the Salmonella/microsome system and by a chromosome test in Chinese hamster (CH) cells. In the mutation test none of the flavorings exhibited significant induction of his+ revertants in Salmonella typhimurium TA98 or TA100, either with or without rat-liver microsome as the metabolic activation system. On the other hand, in the chromosome test most of the agents induced severe chromosome aberration in the treated CH cells, suggesting a potential genotoxicity.
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