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  • Title: [Chromosomal abnormalities of the blastic phase of chronic myeloid leukemia].
    Author: Stoll C.
    Journal: Pathol Biol (Paris); 1982 Nov; 30(9):755-8. PubMed ID: 6760078.
    Abstract:
    The chromosomal involvement in the development of malignancy in chronic myeloid leukemia is not a random event. A second Ph1, a trisomy 8, an isochromosome 17q, a trisomy 17 are the main abnormalities. These aberrations use to occur as a karyotypic evolution, either simple or complicated. An extra-medullary development of blastic transformation was demonstrated by chromosomal analysis. It is difficult to demonstrate a correlation between chromosomal abnormalities and clinical evolution in the acute phase of chronic myeloid leukemia.
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