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  • Title: Significance of chromosome abnormalities in leukemia.
    Author: Lawler SD.
    Journal: Semin Hematol; 1982 Oct; 19(4):257-72. PubMed ID: 6760404.
    Abstract:
    The review deals with technical considerations in relation to culturing and studying the chromosomes of leukemic cells. Specific and non-random chromosomal changes are described by the historic approach. Then follows a description of the application of chromosomal studies to diagnosis, progress and followup in the chronic and acute leukemias. A section is devoted to the application of chromosomal studies in bone-marrow transplantation. Finally, lines of research for leukemia using a genetic approach are suggested.
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