These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The basal membrane of the kidney].
    Author: Monnens LA.
    Journal: Tijdschr Kindergeneeskd; 1982 Oct; 50(5):121-30. PubMed ID: 6760458.
    Abstract:
    The glomerular basement membrane consists of the lamina densa and two laminae rarae. The glomerular basement membrane (GBM) functions as both the size and the charge barrier to filtration of macromolecules. Several substances have been localized in the GBM: collagen type IV, V, laminin, entactin, fibronectin, amyloid P and proteoglycans. Anionic sites are present on the epithelial and endothelial cell surface (the cell coat or glycocalyx) due to the presence of sialic acid. The negative charges in the GBM concentrate in the lamina rara interna and lamina rara externa. This anionic charge is in large part caused by heparansulphate. Congenital abnormalities of the biochemical composition are expected in the congenital nephrotic syndrome, in minimal change nephropathy, in Alport's syndrome, in Laurence-Moon-Biedl syndrome and in nail-patella syndrome. The main function of the tubular basement membrane (TBM) is to provide support to the epithelium. The chemical composition of TBM differs from the composition of GBM. Some forms of polycystic disease can perhaps be explained by an abnormal chemical composition of TBM.
    [Abstract] [Full Text] [Related] [New Search]