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  • Title: Suppression of GVH reaction in F1 hybrid mice by foetal liver cells.
    Author: Siegl E, Brock J, Schulze HA.
    Journal: Folia Biol (Praha); 1982; 28(6):409-14. PubMed ID: 6761153.
    Abstract:
    The effect of foetal liver cells on GVH reaction with the parental lymphocytes in F1 hybrid mice was studied. The GVH reaction was induced in newborn (CBA X C3H)F1 and in 10-day-old (CBA X C57BL/6)F1 hybrid mice. Foetal liver cells did not induce a GVH reaction. The GVH reaction of CBA spleen cells in (CBA X C3H)F1 hybrid mice was demonstrable, although weak. Foetal liver cells suppressed the GVH reaction, in dependence on cell concentration, in (CBA x C3H)F1 but not in (CBA X C57BL/6)F1 hybrid mice. The possibility to induce transplantation tolerance with foetal liver cells is discussed.
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