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  • Title: Three controlled trials of weight loss with phenylpropanolamine.
    Author: Altschuler S, Conte A, Sebok M, Marlin RL, Winick C.
    Journal: Int J Obes; 1982; 6(6):549-56. PubMed ID: 6761288.
    Abstract:
    A multisite double-blind study was designed to determine the effectiveness of a phenylpropanolamine-caffeine combination in achieving weight loss. Two-hundred and one obese adult patients were divided into three separate groups in which phenylpropanolamine/caffeine was compared with either placebo (6 weeks), mazindol (6 weeks), or diethylpropion (8 weeks). In these clinical trials, phenylpropanolamine/caffeine proved to be as effective as mazindol and diethylpropion and significantly more effective than placebo in achieving weight loss. Overall, phenylpropanolamine/caffeine had fewer side effects than mazindol and diethylpropion. Its use as an effective anorectic agent in the treatment of obesity is reviewed.
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