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  • Title: Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine.
    Author: Thoene JG, Lemons RM.
    Journal: Biochem J; 1982 Dec 15; 208(3):823-30. PubMed ID: 6762213.
    Abstract:
    The accumulation of cystine in cystinotic fibroblasts from free and protein-linked cystine has been investigated. Cystine is not accumulated from cysteine but is readily accumulated from cystine. The accumulation from free cystine does not occur as a result of pinocytosis or from the degradation of a rapidly metabolized protein pool. Further studies of the degradation of disulphide-containing proteins by these cells may aid understanding of the mechanisms of proteolysis.
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