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  • Title: Serodiagnosis of Varicella-Zoster virus infection in pregnancy and standardization of the ELISA IgG and IgM antibody tests.
    Author: Enders G.
    Journal: Dev Biol Stand; 1982; 52():221-36. PubMed ID: 6762304.
    Abstract:
    It is recognized that varicella virus infection in early pregnancy may cause severe congenital malformation and that varicella virus infection during the last 4 days of gestation until 48 h. after delivery can be dangerous for the child. Maternal Zoster has also been suggested as a cause of some congenital defect, but this association is poorly documented. Sensitive, specific and rapid indirect (ELISA) and direct (ELA) enzyme-linked-immunoassays for detecting Varicella and Herpes simplex virus, IgM-, IgA and IgG antibodies are employed for serodiagnosis of infection in the mother and the newborn and for determining the immunity status in high risk individuals who are exposed to V-Z infection. In the latter situation serological findings may serve as a guide for passive immunisation with Zoster-hyperimmunoglobulin (ZIG). The antibody concentration of the latter can now easily be standardized by the indirect ELISA-IgG-test. For determining the antibody concentration in the patient's sera in the indirect and direct ELISA with the method of Mona (Multiples of normal activity) a standardized test procedure using 2 optimal working dilutions has been established.
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